It is also associated with a poor prognosis due to its clinical behavior and lack of molecular targets for cancer therapy. TN cancer tends to be more aggressive than other types of breast cancer. An overview of triple-negative breast cancer. Triple-negative (TN) subtype is defined as a breast cancer with negative expression of estrogen/progesterone (ER/PR) hormone receptors and human epidermal growth factor receptor-2 (HER2) (either by immunohistochemistry or by fluorescent in situ hybridization ) 2 2. It is classified into molecular subtypes, based on the lack of protein expression of estrogen receptor (ER) and progesterone receptor (PR) and the absence of overexpression of human epidermal growth factor 2 receptor (HER2). Molecular portraits of human breast tumours. Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Survival analysis Prognosis Medical records Pathological conditions Anatomical Triple-negative breast neoplasmsīreast cancer is a heterogeneous disease involving multiple genetic alterations 1 1. CONCLUSIONS:Īdvanced clinical stage, positive sentinel lymph node, axillary node involvement, surgical treatment with mastectomy, and higher residual cancer burden were related to a significant reduction in OS and DFS and increased risk of mortality and recurrence in TNBC. The 10-year OS and DFS was around 61 and 65%, respectively. Smoking, advanced clinical stage, larger tumor size, angiolymphatic invasion, positive sentinel lymph node, axillary node involvement, higher cancer burden, surgical treatment with mastectomy, and recurrence were related to a significant decrease in OS and/or DFS and increased risk of mortality and/or recurrence in TNBC. Univariate analysis (log-rank test) and multivariate analysis (Cox regression) were used to examine prognostic factors related to a statistically significant reduction (p<0.05) in OS and DFS and increased risk of mortality and tumor recurrence. OS and DFS were estimated by the Kaplan-Meier model. Ten medical records were excluded, and the final sample was composed of 83 women with TNBC. Of these patients, 93 (17%) were women with TNBC. Medical records of 532 patients with breast cancer diagnosed from 2007 to 2020 were analyzed. This is a retrospective observational cohort study. This study aims to analyze prognostic factors related to a reduction in overall survival (OS), disease-free survival (DFS), and risk of mortality and recurrence in TNBC. Triple-negative breast cancer (TNBC) is characterized by lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression and accounts for 15–20% of all breast cancers.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |